Fragrance Skin Sensitization Evaluation and Human Testing
نویسندگان
چکیده
منابع مشابه
Predicting absorption of fragrance Chemicals through human skin
In the endeavor to identify a mathematical model predictive of the mostly unexplored skin penetration of fragrance chemicals, the Potts-Guy equation was tested here by correlating the published, measured Kp for 20 such compounds with predicted Kp values. The data, covering a broad range of structures, are well described by that model (r 2 = 0.86, p < 0.001). Also, calculated octanol-water parti...
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Skin sensitization is a major environmental and occupational health hazard. Although many chemicals have been evaluated in humans, there have been no efforts to model these data to date. We have compiled, curated, analyzed, and compared the available human and LLNA data. Using these data, we have developed reliable computational models and applied them for virtual screening of chemical librarie...
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For years, methods have been available for the predictive identification of chemicals that possess the intrinsic potential to cause skin sensitization. However, many have proven less suitable for the determination of relative sensitizing potency. In this respect, the local lymph node assay (LLNA) has been shown to have a number of important advantages. Through interpolation of LLNA dose-respons...
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Unilever initiated a long-term research and capability development program in 2004 to evaluate and implement a new conceptual approach for assuring consumer safety without animal testing (Fentem et al., 2004, Westmoreland et al., 2010). Unilever’s approach for safety assessment is risk-based, meaning that all available data on a new ingredient (including predicted levels of consumer exposure du...
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Allergic contact dermatitis resulting from skin sensitization is a common occupational and environmental health problem. In recent years, the local lymph node assay (LLNA) has emerged as a practical option for assessing the skin-sensitization potential of chemicals. In addition to accurate identification of skin sensitizers, the LLNA can also provide a reliable measure of relative sensitization...
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ژورنال
عنوان ژورنال: Dermatitis
سال: 2020
ISSN: 1710-3568
DOI: 10.1097/der.0000000000000684